Thymol Turbidity as a Liver Function Test
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The thymol turbidity and cephalin-cholesterol tests, euglobulin, albumin-globulin ratio and serology in leprosy.
During the course of experimental work on leprous patients in Hawaii, Dr. Eric Fennel observed a relationship between the thymol turbidity and cephalin-ehoiesteroi tests, the albumin: globulin ratio and the degree of skin involvement in the cases he studied. He made observations on 25 cases and included some of his fi ndings in a report on the thymol turbidity test (4), but he felt that they we...
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DESPITE numerous tests used in the diagnosis of liver disease, in manv cases it is still difficult to decide whether there is liver damage, and if so, how much. This study was done to evaluate serum pseudocholinesterase estimation as a routine test of liver function, and to conmpare it with certain commonly used tests, viz., serum bilirubin, zinc sulphate flocculation test, thymol turbidity tes...
متن کاملA study of the thymol turbidity test with special reference to buffer behavior. Formulation of a modified reagent using tris-hydroxymethylaminomethane.
Replacement of barbiturate buffer by a tris-hydroxymethylaminomethane buffer in the thymol test reagent of Maclagan greatly improves the stability of the reagent. Thymol turbidity measurements made by means of the modified reagent agreed closely with those made with barbiturate-containing reagents. However in hyperlipemic sera, the latter reagent gave higher turbidities. A reaction of barbitura...
متن کاملThe interrelations of the serum proteins in liver damage, with special reference to the thymol test.
Maclagan (1944a) demonstrated that phenol and certain derivatives when dissolved in barbiturate buffer at pH 7.8 produced a turbidity with human sera. He observed that under specified conditions sera from normal persons gave a negligible turbidity, and the most marked turbidities occurred with sera from patients suffering from parenchymatous liver damage. The concentrations of phenol or phenol ...
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Prolonged or permanent impairment of liver function is now known to occur in a variable proportion of patients following an attack of infectious hepatitis or serum jaundice (1-11). However, the incidence of this chronic hepatic disease is not well established because of the difficulty in correlating symptomatology with the available liver function tests or with liver biopsy (12-15). Of the mean...
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